Fasalka Nadiifinta Sare ee Caafimaadka budada Nicotinamide

Macluumaadka Alaabta

Niacinamide: Nicotinamide waxaa iska leh dhexdhexaadiyeyaasha pyridine ee Dhexdhexaadiyeyaasha Farmashiyaha. Waa xarun ka kooban giraanta pyridine iyo koox amide ah. Waa nooc ka mid ah fitamiin B3 waxaana si weyn looga isticmaalaa warshadaha dawooyinka iyo nafaqeynta.

Nikotinamide, oo sidoo kale loo yaqaan nicotinamide, waa isku dhafka amide ee nicotinic acid. Budada crystalline cad; ur aan ur lahayn ama ku dhawaad ​​ur, dhadhan qadhaadh; wax yar hygroscopic. Ku milmay biyo ama ethanol, ku milmay glycerol. Waxaa loo isticmaalaa kiliinikada si loola dagaallamo pellagra, stomatitis, bararka luqadda, xanuunka sinus node syndrome, iyo xannibaadda atrioventricular.

Ilaha ugu muhiimsan ee niacinamide
Waxaa laga helaa dabeecadda inta badan maqaarka sare ee badarka, khamiirka, lawska, hilibka, xubinta xoolaha, caanaha iyo khudaarta cagaaran. Waxaa laga soo saari karaa tryptophan ee jirka, laakiin leh waxtarkeedu aad u hooseeyo. Niacin waxaa isku dubaridi kara Escherichia coli (Escherichiacoli) iyo kuwa kale ee xiidmaha, ka dibna loo beddelo nicotinamide.
Hababka wax soo saarka ee nicotinamide
(1) β-methyl pyridine waxaa oksidheen ku ah nicotinic acid hawada, tan dambena waxaa soo saara ficilka ammonium hydroxide ka dibna kuleyl iyo fuuqbax.
(2) nicotinic acid, boric acid iyo ammonia galay dheriga falcelinta, walaaqaya dhex ammonia, kala diri heerkulka; ka dibna dib u soo kabashada ammonia ilaa 120 ~ C ka dibna u guurto dheriga fuuqbaxa si ay u sii wadaan xoogga; Marka heerkulku gaaro 145 ° C wuxuu bilaabay inuu ku daro ammonia dareere ah, oo sii wad inaad gudbiso falcelinta ammonia 185 ~ 190 ° C 20 ~ 30 h. Ka dibna la qaboojiyey ilaa 130 ° C, lagu qasi jiray biyo nadiif ah, ku dar kaarboon firfircoon, iyo 70 ~ 80 ~ C falcelinta ka dib, shaandhaynta inta kulul, shaandheynta waa qabow qabow oo biyo ah 24h, kala sooc iyo crystallized, oo lagu dhaqo ethanol, qalajiyey oo dhameeyay, soo saar 89%.
(3) ku rid nicotinic acid, boric acid iyo ammonia dheriga falcelinta, walaaqaya ammonia, kulaalaya si uu u milmo, ka dibna u distillate si uu u soo kabsado ammonia, ilaa 120 ℃ ka dibna u gudub dheriga fuuqbaxa si ay u sii wadaan inay xoogga saaraan marka heerkulku gaaro 145 ℃ si loogu daro dareeraha ammonia ammonia 20-30h, ka dibna la qaboojiyey ilaa 130 ℃, ku dar biyo distilled si ay u milo, dar kaarboon firfircoon, iyo gudbi falcelinta ammonia at 70-80 ℃ Decolorization 2h, ka dib markii falcelinta halka sifaynta kulul, sifeeyo in roobka qabow ee biyaha 24h, kala soocidda iyo crystallization% engegan, dhalidda iyo crystallization% engegan, dhalidda iyo crystallization% engegan.
(4) Waxaa lagu helaa cusbada nicotinic acid ammonia ka dibna fuuqbaxa.

Macluumaadka shirkadda

Waxyaalaha ay shirkadu soo dejiso iyo wax-soo-saarka dhoofinta ugu badan waxaa ka mid ah

(1) Daaweynta Biyaha: Habka daaweynta biyaha waxaa ka mid ah daaweynta jirka iyo daaweynta kiimikada. Hababka daaweynta biyaha bini'aadamku waxay ahaayeen dhowr sano oo taariikhda ah, hababka jireed, oo ay ku jiraan isticmaalka noocyo kala duwan oo kala duwan oo kala duwan oo kala duwan oo ah walxaha shaandhada, isticmaalka xayaysiinta ama habka xannibaadda, wasakhda biyaha ka baxsan, habka adsorption ee ka sii muhiimsan ee xayeysiinta kaarboonka firfircoon, habka xannibaadda waa in biyaha loo maro walxaha shaandhada, si wasakhda biyaha, cabbirka nadiifka ah aysan u gudbin karin.

(2) Alaabooyinka caagga ah waxay ka samaysan yihiin caag cayriin ah oo loogu talagalay mashiinka isku dhafka caagga ah ka dib markii la sifeeyo sida alaabta ceeriin, sifeynta caagga iyadoo loo eegayo sifooyinka alaabta caagga ah ee loo baahan yahay iyo qaababka naqshadeynta, waxayna dejiyaan adkaanta alaabta loo baahan yahay. Alaabta waxaa lagu qaabeeyay mashiinka vulcanizing saxan caag ah. Ka dib qaabaynta, alaabada ayaa ugu dambeyntii lagu farsameeyaa gees duulaya si loo sameeyo oogada alaabta mid siman oo aan bur-bur lahayn.